Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

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http://www.wikidata.org/entity/Q46902087
NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding siteAromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPaseSmall molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata.Kinesin-5 inhibitor resistance is driven by kinesin-12A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.Mitosis as an anti-cancer drug target.Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.Kinesin spindle protein SiRNA slows tumor progression.Using transcriptome sequencing to identify mechanisms of drug action and resistance.Intratumor RNA interference of cell cycle genes slows down tumor progression.Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC).Cancer drug therapy and stochastic modeling of "nano-motors"
P2860

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

Item
http://www.wikidata.org/entity/Q46902087
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@en
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@nl
type
label
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@en
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@nl
prefLabel
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@en
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Discovery and biochemical char ...... the human mitotic kinesin KSP.
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698