PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.
about
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destructionSkp2: a novel potential therapeutic target for prostate cancerHigh Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate CancerPhenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo.Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cellsSkp2 is a promising therapeutic target in breast cancer.Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.Knockdown of Mediator Complex Subunit 19 Suppresses the Growth and Invasion of Prostate Cancer CellsFoxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex.Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissuesTissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways.Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.Ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells.Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation.Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex.TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer.Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression.PTEN/Akt-p27(kip1) Signaling Promote the BM-MSCs Senescence and Apoptosis in SLE Patients.
P2860
Q24602385-D2F352B0-1861-41C3-B86A-5242AABA5C41Q24625558-37A8D2DB-830B-43F9-A7AB-B51D2B0DF6EBQ26774902-11DB3A99-463F-4F9C-A864-CD9B404E66BFQ33724512-BF676D40-2487-40C6-BCEF-8B86962E889CQ33779578-839AEE1D-7D57-4FB8-8ABC-9A10D4D0212BQ35687208-FF001C9B-F411-44E0-8731-BEF3CFA5146CQ35740051-B9825901-BF77-4BE2-99AB-7DF590269E6AQ36261460-86D0FCCE-BF51-4DC7-9283-B4CF85F5569CQ36508271-BEDCCCF4-D83A-4B49-8638-88509C411B84Q37030885-F306B6A1-5C82-4B4F-84C5-5A31593B54D7Q37239331-8913B668-8431-4660-AA52-70B9CBEE98A6Q37691234-063D1AE1-354D-4CC2-AA61-CA7B91D67152Q38885436-C7F983EF-B395-4A98-901B-3AC5AABF064FQ39643015-C79FF4A8-A4D3-43CC-860D-0B91E03F204EQ39910354-5DED6A90-E470-4BBE-B525-7A9569313F9BQ40271317-B9E1C26C-BBBF-4B4D-9EC0-71E0F1810C6FQ41154107-672944EC-92BB-4748-B5D2-F14B3750A203Q42961775-A940F952-A7E6-4251-8175-7B28B6546ED2Q43097731-328370F0-A5B3-4D2B-863D-A1C72E35EAC9Q45098656-892276EB-9A1B-4138-B0D4-D45A71D5728DQ53626937-8E654BD6-E8E7-4433-A980-4CE5F408AC25
P2860
PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@en
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@nl
type
label
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@en
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@nl
prefLabel
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@en
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@nl
P356
P1433
P1476
PI3K/Akt signaling regulates p ...... tion in LNCaP and PC346 cells.
@en
P2093
Jan Trapman
Petra W van Duijn
P2860
P304
P356
10.1002/PROS.20398
P577
2006-05-01T00:00:00Z