Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing.
about
The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies.Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics.IMAC capture of recombinant protein from unclarified mammalian cell feed streamsQuantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb producing CHO-S cell line.Proteomic analysis of host cell protein dynamics in the supernatant of Fc-fusion protein-producing CHO DG44 and DUKX-B11 cell lines in batch and fed-batch cultures.The use of 'Omics technology to rationally improve industrial mammalian cell line performance.Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation, Change, and Improvement. A Review of Downstream Processing Developments in Protein Purification.Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.Cell culture media impact on drug product solution stability.An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants.More similar than different: Host cell protein production using three null CHO cell lines.Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry.Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR).Development of adsorptive hybrid filters to enable two-step purification of biologics.Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies.Clearance of the rodent retrovirus, XMuLV, by protein A chromatography.ELISA reagent coverage evaluation by affinity purification tandem mass spectrometry.Toward the complete characterization of host cell proteins in biotherapeutics via affinity depletions, LC-MS/MS, and multivariate analysis.Host cell proteins in biotechnology-derived products: A risk assessment framework.Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification.Development of advanced host cell protein enrichment and detection strategies to enable process relevant spike challenge studies.Comparison of purification strategies for antibodies used in a broad spectrum host cell protein immunoassay.Identification of an IgG CDR sequence contributing to co-purification of the host cell protease cathepsin D.Characterization of the co-elution of host cell proteins with monoclonal antibodies during protein A purification.Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.Chlorobaculum tepidum growth on biogenic S(0) as the sole photosynthetic electron donor.Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations.A novel approach to characterize host cell proteins associated with therapeutic monoclonal antibodies.Toward improved host cell protein impurity assessment.Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product.Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.
P2860
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P2860
Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Identification and characteriz ...... clonal antibody bioprocessing.
@en
Identification and characteriz ...... clonal antibody bioprocessing.
@nl
type
label
Identification and characteriz ...... clonal antibody bioprocessing.
@en
Identification and characteriz ...... clonal antibody bioprocessing.
@nl
prefLabel
Identification and characteriz ...... clonal antibody bioprocessing.
@en
Identification and characteriz ...... clonal antibody bioprocessing.
@nl
P2093
P2860
P356
P1476
Identification and characteriz ...... clonal antibody bioprocessing.
@en
P2093
Kelvin H Lee
Kristin N Valente
Leila H Choe
Nicholas E Levy
P2860
P304
P356
10.1002/BIT.25158
P577
2013-12-11T00:00:00Z