about
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancerSignaling by target of rapamycin proteins in cell growth controlInsulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.The PI3K-PDK1 connection: more than just a road to PKBEssential role of PDK1 in regulating cell size and development in miceProtein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentmTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsPhosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinasesS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwaySpatial regulation of the mTORC1 system in amino acids sensing pathwayThe tuberous sclerosis complexRegulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthExpression of Drosophila FOXO regulates growth and can phenocopy starvationControlling how many cells make a flyShrinkage control: regulation of insulin-mediated growth by FOXO transcription factorsThe Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingDifferences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progressionHow are the sizes of cells, organs, and bodies controlled?C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.The temporal requirements for insulin signaling during development in Drosophila.The developmental control of size in insectsmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationMechanisms of TSC-mediated control of synapse assembly and axon guidanceTIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growthMutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin ResistanceEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.mTOR inhibitors in cancer therapyRegulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathwayTarget of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alphaRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathwayRole of pescadillo in the transformation and immortalization of mammalian cellsGenetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster.Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neuronsIslet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Drosophila S6 kinase: a regulator of cell size.
@en
Drosophila S6 kinase: a regulator of cell size.
@nl
type
label
Drosophila S6 kinase: a regulator of cell size.
@en
Drosophila S6 kinase: a regulator of cell size.
@nl
prefLabel
Drosophila S6 kinase: a regulator of cell size.
@en
Drosophila S6 kinase: a regulator of cell size.
@nl
P2093
P1433
P1476
Drosophila S6 kinase: a regulator of cell size.
@en
P2093
P304
P356
10.1126/SCIENCE.285.5436.2126
P407
P577
1999-09-01T00:00:00Z