Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

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MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells.An orthotopic glioblastoma animal model suitable for high-throughput screenings

P2860

Q55398218-4A4BDA75-774A-47E5-9F77-DD58454996BD Q57291651-D1C12F68-2FDC-4994-9D41-B16F5500B73D

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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Item

http://www.wikidata.org/entity/Q47097367

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

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2017年學術文章

@yue

2017年學術文章

@zh-hant

name

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@en

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@nl

type

Item

label

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@en

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@nl

prefLabel

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@en

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

@nl

P1476

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1

@en

P2093

Andreas Höglund

http://www.w3.org/2001/XMLSchema#string

Christina Kalderén

http://www.w3.org/2001/XMLSchema#string

Kumar Sanjiv

http://www.w3.org/2001/XMLSchema#string

Lars Bräutigam

http://www.w3.org/2001/XMLSchema#string

Linda Pudelko

http://www.w3.org/2001/XMLSchema#string

Pegah Rouhi

http://www.w3.org/2001/XMLSchema#string

Steven Edwards

http://www.w3.org/2001/XMLSchema#string

Thomas Helleday

http://www.w3.org/2001/XMLSchema#string

Ulrika Warpman Berglund

http://www.w3.org/2001/XMLSchema#string

P2860

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

Targeting Aggressive Cancer Stem Cells in Glioblastoma

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Identification of human brain tumour initiating cells

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

The somatic genomic landscape of glioblastoma

Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

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84671-84684

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scholarly article

P356

10.18632/ONCOTARGET.19404

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English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Daniel Hägerstrand

Alberto J Schuhmacher

Massimo Squatrito

Helge Gad

P577

2017-07-20T00:00:00Z

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29156675

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P932

5689565

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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

about

P2860

P2860

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932