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Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape EnhancersSmall structural differences of targeted anti-tumor toxins result in strong variation of protein expression.The distribution of saponins in vivo affects their synergy with chimeric toxins against tumours expressing human epidermal growth factor receptors in mice.Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.Ribosome-inactivating and related proteins.Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin.MicroRNAs as New Bioactive Components in Medicinal Plants.Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina.Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides.Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma.Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.Reporter assay for endo/lysosomal escape of toxin-based therapeutics.Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells.Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge.Triterpenoid saponins from the roots of Gypsophila trichotoma Wender.Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice.Saponins modulate the intracellular trafficking of protein toxins.The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins.The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins.A convenient method for saponin isolation in tumour therapy.Epidermal growth factor receptor expression affects the efficacy of the combined application of saponin and a targeted toxin on human cervical carcinoma cells.Enhancement of toxicity of saporin-based toxins by Gypsophila saponins--kinetic of the saponin.A simple method for isolation of Gypsophila saponins for the combined application of targeted toxins and saponins in tumor therapy.Soapwort saponins trigger clathrin-mediated endocytosis of saporin, a type I ribosome-inactivating protein.Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861.Electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor-specific cytotoxicity of targeted toxins.Enhancement of cytotoxicity of ribosome-inactivating-protein type I by saponinum album is not based on stimulation of phagocytosis.Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins.Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement.
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alexander Weng
@ast
Alexander Weng
@en
Alexander Weng
@es
Alexander Weng
@nl
Alexander Weng
@sl
type
label
Alexander Weng
@ast
Alexander Weng
@en
Alexander Weng
@es
Alexander Weng
@nl
Alexander Weng
@sl
prefLabel
Alexander Weng
@ast
Alexander Weng
@en
Alexander Weng
@es
Alexander Weng
@nl
Alexander Weng
@sl
P106
P21
P31
P496
0000-0003-1640-2189