Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications.

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Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Characterization of the APLF F ...... l and functional implications.

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Characterization of the APLF F ...... l and functional implications.

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Characterization of the APLF F ...... l and functional implications.

@en

Characterization of the APLF F ...... l and functional implications.

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Characterization of the APLF F ...... l and functional implications.

@en

Characterization of the APLF F ...... l and functional implications.

@nl

P1476

Characterization of the APLF F ...... l and functional implications.

@en

P2093

Eugene F DeRose

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Kyungmin Kim

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Robert E London

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P2860

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

APLF promotes the assembly and activity of non-homologous end joining protein complexes

The FHA domain of aprataxin interacts with the C-terminal region of XRCC1

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

PARP-3 and APLF function together to accelerate nonhomologous end-joining

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

P304

12374-12387

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scholarly article

P356

10.1093/NAR/GKX941

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P407

English

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P478

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P50

Lars C Pedersen

Thomas W Kirby

P577

2017-10-20T00:00:00Z

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P698

29059378

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P932

5716189

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