HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. - Wikidata - awgldk - TriplyDB

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

http://www.wikidata.org/entity/Q47154700

about

Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Heterogeneity of glycolysis in cancers and therapeutic opportunities.Metabolic control of cancer cell stemness: Lessons from iPS cells Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells Atypical cell populations associated with acquired resistance to cytostatics and cancer stem cell features: the role of mitochondria in nuclear encapsulation Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming.Pluripotent stem cell energy metabolism: an update miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency.Activators of PKM2 in cancer metabolism.Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency.Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.The return of metabolism: biochemistry and physiology of the pentose phosphate pathway Different Blood Cell-Derived Transcriptome Signatures in Cows Exposed to Vaccination Pre- or Postpartum.Connecting Mitochondria, Metabolism, and Stem Cell Fate.Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.Both high expression of pyruvate kinase M2 and vascular endothelial growth factor-C predicts poorer prognosis in human breast cancer Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function Metabolic Reprogramming of Stem Cell Epigenetics.NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency.Energy metabolism in the acquisition and maintenance of stemness.Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch.Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer.Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas.A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.Mitochondrial Heteroplasmy.Metabolic restructuring and cell fate conversion.Concise review: induced pluripotency by defined factors: prey of oxidative stress.The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development.Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.Mitochondrial DNA heteroplasmy in human health and disease.Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?Metabolic remodeling in early development and cardiomyocyte maturation.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.

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P2860

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

http://www.wikidata.org/entity/Q47154700

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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2014年學術文章

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name

HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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type

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HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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HIF1α modulates cell fate repr ...... regulation of PDK1-3 and PKM2.

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Katharina Blümlein

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Katharina Drews

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Nadine Rohwer

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Raul Bukowiecki

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Sheila Hoffmann

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P2860

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

Rapid evolution of animal mitochondrial DNA

Understanding the Warburg effect: the metabolic requirements of cell proliferation

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

Mitochondrial DNA mutations in human disease

Hypoxia-inducible factors in physiology and medicine

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364-376

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10.1002/STEM.1552

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2

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32

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Thorsten Cramer

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Alessandro Prigione

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2014-02-01T00:00:00Z

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260306528

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24123565

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5730046

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