Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.

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http://www.wikidata.org/entity/Q47249680
Epothilones: From discovery to clinical trialsC6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.Conformation-activity relationships of polyketide natural products.Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin.Total synthesis and selective activity of a new class of conformationally restrained epothilonesNew sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue.Design, synthesis and biological evaluation of bridged epothilone D analogues.Conformational preferences of zampanolide and dactylolide.Synthesis of isotopically labeled epothilones.Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues.Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned.The binding mode of side chain- and C3-modified epothilones to tubulin.Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.Comparative binding energy (COMBINE) analysis supports a proposal for the binding mode of epothilones to β-tubulin.Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations.
P2860

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.

Item
http://www.wikidata.org/entity/Q47249680
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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2003年學術文章
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name
Conformation-activity relation ...... ve conformation of epothilone.
@en
Conformation-activity relation ...... ve conformation of epothilone.
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type
label
Conformation-activity relation ...... ve conformation of epothilone.
@en
Conformation-activity relation ...... ve conformation of epothilone.
@nl
prefLabel
Conformation-activity relation ...... ve conformation of epothilone.
@en
Conformation-activity relation ...... ve conformation of epothilone.
@nl
P1433
P1476
P2093
P2860
P304
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P356
P433
P478
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Conformation-activity relation ...... ve conformation of epothilone.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698