LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
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Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers.Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation.Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational researchRegulation of hepatic ABCC transporters by xenobiotics and in disease states.A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease.E. coli infection modulates the pharmacokinetics of oral enrofloxacin by targeting P-glycoprotein in small intestine and CYP450 3A in liver and kidney of broilers.Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.A histologic scoring system for prognosis of patients with alcoholic hepatitisThe molecular pathogenesis of cholestasis in sepsisCholestatic liver (dys)function during sepsis and other critical illnesses.Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.Potential Hepatotoxicities of Intravenous Fat Emulsions in Infants and Children.Liver - guardian, modifier and target of sepsis.Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Expression of Drug Pump Protein MRP2 in Lipopolysaccharide-Treated Rats and its Impact on the Disposition of AcetaminophenLPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanism(s).Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway.Induction of multidrug resistance-associated protein 2 in liver, intestine and kidney of streptozotocin-induced diabetic rats.Regulation of human liver delta-aminolevulinic acid synthase by bile acids.Lipopolysaccharide exposure augments isoniazide-induced liver injury.Phytosterols Synergize With Endotoxin to Augment Inflammation in Kupffer Cells but Alone Have Limited Direct Effect on Hepatocytes.Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids.De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy.
P2860
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P2860
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
LPS-induced downregulation of ...... a posttranscriptional process.
@en
LPS-induced downregulation of ...... a posttranscriptional process.
@nl
type
label
LPS-induced downregulation of ...... a posttranscriptional process.
@en
LPS-induced downregulation of ...... a posttranscriptional process.
@nl
prefLabel
LPS-induced downregulation of ...... a posttranscriptional process.
@en
LPS-induced downregulation of ...... a posttranscriptional process.
@nl
P2093
P2860
P356
P1476
LPS-induced downregulation of ...... a posttranscriptional process
@en
P2093
Annelies L Draaisma
Dirk K F Meijer
Geny M M Groothuis
Klaas Nico Faber
Maarten J H Slooff
Marieke G L Elferink
Marjolijn T Merema
P2860
P304
P356
10.1152/AJPGI.00071.2004
P50
P577
2004-06-17T00:00:00Z