A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation.

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A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation.

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2017 nî lūn-bûn

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A mechanistic model to predict ...... d aggregation and degradation.

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A mechanistic model to predict ...... d aggregation and degradation.

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A mechanistic model to predict ...... d aggregation and degradation.

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A mechanistic model to predict ...... d aggregation and degradation.

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A mechanistic model to predict ...... d aggregation and degradation.

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A mechanistic model to predict ...... d aggregation and degradation.

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P1476

A mechanistic model to predict ...... d aggregation and degradation.

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P2093

Regina M Murphy

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Tyler J Perlenfein

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P2860

Cystatin C modulates cerebral beta-amyloidosis

Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases

The amyloid hypothesis of Alzheimer's disease at 25 years

Cysteine cathepsins: from structure, function and regulation to new frontiers

Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping

The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

Trafficking and proteolytic processing of APP

Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis

P304

21071-21082

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scholarly article

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10.1074/JBC.M117.811448

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English

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292

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P577

2017-10-18T00:00:00Z

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29046353

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5743080

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