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A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T CellsHuman and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen ComplexV 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigenGlycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T CellsRecognition of lyso-phospholipids by human natural killer T lymphocytes.A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivityΑ-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agentsA rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoireCloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab)Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.The molecular bases of δ/αβ T cell-mediated antigen recognition.Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolasesImmunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.The Alpha and Omega of Galactosylceramides in T Cell Immune Function.Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d.A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.Natural killer T-cell autoreactivity leads to a specialized activation stateKinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activationSynthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.Synthesis of a 2"-deoxy-β-GalCerNatural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells.Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation.A Solvent-free Approach to Glycosyl Amides: Towards the Synthesis of α-N-Galactosyl Ceramides.Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation.Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.Silicon acceleration of a tandem alkene isomerization/electrocyclic ring-opening of 2-methyleneoxetanes to α,β-unsaturated methylketones.Toward a formal synthesis of laureatin: unexpected rearrangements involving cyclic ether nucleophiles.Directed ring-opening of 1,5-dioxaspiro[3.2]hexanes: selective formation of 2,2-disubstituted oxetanes.Straightforward synthesis of sphinganines via a serine-derived Weinreb amide.Multiphoton excited fabrication of collagen matrixes cross-linked by a modified benzophenone dimer: bioactivity and enzymatic degradation.Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.Synthesis of epi-oxetin via a serine-derived 2-methyleneoxetane.Pt-catalyzed rearrangement of oxaspirohexanes to 3-methylenetetrahydrofurans: scope and mechanism.
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hulumtuese
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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Amy R. Howell
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7102028969
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0000-0003-1958-6411