about
Myostatin: expanding horizonsMyostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle.Mega roles of microRNAs in regulation of skeletal muscle health and diseaseHuman myostatin negatively regulates human myoblast growth and differentiation.Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle.Muscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during dexamethasone-mediated atrophy.Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27.Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes.The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.Myostatin inhibits rhabdomyosarcoma cell proliferation through an Rb-independent pathway.Inactivation of PPARβ/δ adversely affects satellite cells and reduces postnatal myogenesis.Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy.Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins.Irisin treatment improves healing of dystrophic skeletal muscle.Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism.Proteolytic processing of myostatin is auto-regulated during myogenesis.Body fat partitioning does not explain the interethnic variation in insulin sensitivity among Asian ethnicity: the Singapore adults metabolism study.Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway.Myostatin signals through Pax7 to regulate satellite cell self-renewalLack of myostatin reduces MyoD induced myogenic potential of primary muscle fibroblastsMyostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-β signaling by decorinLack of Smad3 signaling leads to impaired skeletal muscle regenerationIdentification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wastingLoss of Parkin impairs mitochondrial function and leads to muscle atrophyG protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cellsMitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicitiesInhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Craig McFarlane
@ast
Craig McFarlane
@en
Craig McFarlane
@es
Craig McFarlane
@nl
Craig McFarlane
@sl
type
label
Craig McFarlane
@ast
Craig McFarlane
@en
Craig McFarlane
@es
Craig McFarlane
@nl
Craig McFarlane
@sl
prefLabel
Craig McFarlane
@ast
Craig McFarlane
@en
Craig McFarlane
@es
Craig McFarlane
@nl
Craig McFarlane
@sl
P106
P1153
8574801800
P21
P31
P496
0000-0002-7056-8887