about
Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's diseaseMotivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance.Tests to assess motor phenotype in mice: a user's guide.Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3.Cognitive deficits in animal models of basal ganglia disorders.Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model.Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling.The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease.In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington's Disease Mouse Model.Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease.Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence.Cognitive training modifies disease symptoms in a mouse model of Huntington's diseaseComparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease DevelopmentA Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's DiseaseA Longitudinal Operant Assessment of Cognitive and Behavioural Changes in the HdhQ111 Mouse Model of Huntington's Disease.Gene expression and behaviour in mouse models of HD.Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease.Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease.Low alcohol preference among the "high alcohol preference" C57/BL10 mice; factors affecting such preference.Nimodipine prevents the effects of ethanol in tests of memory.Effects of corticosterone on place conditioning to ethanol.Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington's disease knock-in mouse.Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice.Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice.Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice.Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes.Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease.Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice.Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice.Selective cognitive impairment in the YAC128 Huntington's disease mouse.Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line.Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice.Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease.Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease.Nimodipine prior to alcohol withdrawal prevents memory deficits during the abstinence phase.Selective increases in regional brain glucocorticoid: a novel effect of chronic alcohol.Social defeat increases alcohol preference of C57BL/10 strain mice; effect prevented by a CCKB antagonist.Assessment of Motor Coordination and Balance in Mice Using the Rotarod, Elevated Bridge, and Footprint Tests.
P50
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hulumtues
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հետազոտող
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Simon P Brooks
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Simon P Brooks
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Simon P Brooks
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Simon P Brooks
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Simon P Brooks
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Simon P Brooks
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Simon P Brooks
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P106
P21
P31
P496
0000-0001-9853-6177