about
Interactions of metals and Apolipoprotein E in Alzheimer's diseaseAge-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionGSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synucleinEnduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by TauThree-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain.Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease.Role of metal ions in the cognitive decline of Down syndrome.The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's diseaseIron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease.Motor and cognitive deficits in aged tau knockout mice in two background strains.Tau protein: relevance to Parkinson's disease.A novel approach to rapidly prevent age-related cognitive declineRescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter.High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer.Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy.A time-course analysis of changes in cerebral metal levels following a controlled cortical impact.The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult BrainCell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.Age modulates the injury-induced metallomic profile in the brain.Restoration of intestinal function in an MPTP model of Parkinson's Disease.Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?Lithium suppression of tau induces brain iron accumulation and neurodegeneration.Is early-life iron exposure critical in neurodegeneration?Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies.Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.Ferroptosis and cell death mechanisms in Parkinson's disease.In vivo prion models and the disconnection between transmissibility and neurotoxicity.Type-1 interferons contribute to the neuroinflammatory response and disease progression of the MPTP mouse model of Parkinson's disease.Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse.Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse.Trehalose improves traumatic brain injury-induced cognitive impairment.Metal chaperones prevent zinc-mediated cognitive decline.Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.
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description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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prefLabel
David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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David I Finkelstein
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P106
P21
P31
P496
0000-0002-8167-4917