The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.
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The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub componentsProtein complexes are under evolutionary selection to assemble via ordered pathwaysParallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.Protein flexibility facilitates quaternary structure assembly and evolution.Combining a NHS ester and glutaraldehyde improves crosslinking prior to MALDI MS analysis of intact protein complexes.Electron-capture dissociation and ion mobility mass spectrometry for characterization of the hemoglobin protein assemblyNinjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.Host-rabies virus protein-protein interactions as druggable antiviral targetsSystematic identification of transcriptional regulatory modules from protein-protein interaction networksComparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case.Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions.Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.How the oxygen tolerance of a [NiFe]-hydrogenase depends on quaternary structure.Empirical power laws for the radii of gyration of protein oligomers.A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.Functional determinants of protein assembly into homomeric complexes.Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.Structural templates for modeling homodimers.Experimental analysis of co-evolution within protein complexes: the yeast exosome as a model.A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.PDB-wide identification of biological assemblies from conserved quaternary structure geometry.Structural and evolutionary versatility in protein complexes with uneven stoichiometry.A Framework for Discovering, Designing, and Testing MicroProteins to Regulate Synthetic Transcriptional Modules.Nondeterministic self-assembly with asymmetric interactions.Illustration of SID-IM-SID (surface-induced dissociation-ion mobility-SID) mass spectrometry: homo and hetero model protein complexes.Productive induced metastability in allosteric modulation of kinase function.
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P2860
The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@en
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@nl
type
label
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@en
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@nl
prefLabel
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@en
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@nl
P2093
P2860
P50
P356
P1476
The emergence of protein compl ...... stery. Colworth Medal Lecture.
@en
P2093
Eviatar Natan
Lucy J Colwell
Sebastian E Ahnert
P2860
P304
P356
10.1042/BST20120056
P577
2012-06-01T00:00:00Z