Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals.
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Peripheral cannabinoid receptor, CB2, regulates bone mass.Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNARegulation of adult bone turnover by sex steroidsAn ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant YodaAltered TNSALP expression and phosphate regulation contribute to reduced mineralization in mice lacking androgen receptor.The effect of oxandrolone treatment on human osteoblastic cells.Signaling pathways implicated in androgen regulation of endocortical boneDoes the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies.Amelioration of type I diabetes-induced osteoporosis by parathyroid hormone is associated with improved osteoblast survivalIncreased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice.Deficiency in perlecan/HSPG2 during bone development enhances osteogenesis and decreases quality of adult bone in miceAndrogen prevents hypogonadal bone loss via inhibition of resorption mediated by mature osteoblasts/osteocytes.Androgens and estrogens in skeletal sexual dimorphism.Sex steroid actions in male boneThe role of GH/IGF-I-mediated mechanisms in sex differences in cortical bone size in miceStreptozotocin, type I diabetes severity and boneCCAAT/enhancer binding protein β-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorptionBody composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation.Bone vs. fat: embryonic origin of progenitors determines response to androgen in adipocytes and osteoblasts.Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes.Local delivery of a selective androgen receptor modulator failed as an anabolic agent in a rat bone marrow ablation modelDelayed pubertal development by hypothalamic suppression causes an increase in periosteal modeling but a reduction in bone strength in growing female rats.Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton.Leptin treatment prevents type I diabetic marrow adiposity but not bone loss in miceA neurotoxic alcohol exposure paradigm does not induce hepatic encephalopathy.Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice.Human androgen deficiency: insights gained from androgen receptor knockout mouse models.Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.Androgen receptor overexpression is neuroprotective in experimental stroke.
P2860
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P2860
Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Targeted overexpression of and ...... phenotype in growing animals.
@en
Targeted overexpression of and ...... phenotype in growing animals.
@nl
type
label
Targeted overexpression of and ...... phenotype in growing animals.
@en
Targeted overexpression of and ...... phenotype in growing animals.
@nl
prefLabel
Targeted overexpression of and ...... phenotype in growing animals.
@en
Targeted overexpression of and ...... phenotype in growing animals.
@nl
P2093
P356
P1433
P1476
Targeted overexpression of and ...... phenotype in growing animals.
@en
P2093
Amber R Toombs
Karl J Jepsen
Michael A Gentile
Shun-ichi Harada
Viera Kasparcova
Xiao-Wei Zhang
P304
P356
10.1210/EN.2003-1016
P407
P577
2004-05-06T00:00:00Z