SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
about
SETD2: a complex role in blood malignancy.Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.SETD2 - linking stem cell survival and transformation.Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature.MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth
P2860
SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年學術文章
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name
SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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type
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SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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SETD2 alterations impair DNA d ...... e to chemotherapy in leukemia.
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P2093
P2860
P1433
P1476
SETD2 alterations impair DNA d ...... ce to chemotherapy in leukemia
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P2093
Andrei V Krivtsov
Benjamin L Ebert
Brenton G Mar
Cecilia A Castellano
James J Hsieh
Jonathan Chabon
Josephine D Kahn
Marie E McConkey
Peter V Grauman
Rebecca L Zon
P2860
P304
P356
10.1182/BLOOD-2017-03-775569
P407
P577
2017-10-10T00:00:00Z