Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.
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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsSuppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-CellsSTAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammationOpinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetesThe immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ.SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destructionTreatment with recombinant tumor necrosis factor-related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetesHedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cellsAutoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodesDNA methylation similarities in genes of black South Africans with systemic lupus erythematosus and systemic sclerosis.Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes.Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.No non-redundant function of suppressor of cytokine signaling 2 in insulin producing β-cells.Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice.SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.The target tissue in autoimmunity--an influential niche.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes.Beta cell apoptosis in diabetes.Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.SOCS1 prevents graft arteriosclerosis by preserving endothelial cell functionSOCS and diabetes--ups and downs of a turbulent relationship.Suppressors of cytokine signaling (SOCS) and type 2 diabetes.SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications.Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis.Co-encapsulation of bioengineered IGF-II-producing cells and pancreatic islets: effect on beta-cell survival.Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus.Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death.In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.Suppressor of Cytokine Signaling-1 Peptidomimetic Limits Progression of Diabetic Nephropathy.NF-κB is weakly activated in the NOD mouse model of type 1 diabetes.Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice.Overexpression of phosphorylated STAT-1alpha in the labial salivary glands of patients with Sjögren's syndrome.Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL
P2860
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P2860
Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Suppressor of cytokine signali ...... diated autoimmune destruction.
@en
Suppressor of cytokine signali ...... diated autoimmune destruction.
@nl
type
label
Suppressor of cytokine signali ...... diated autoimmune destruction.
@en
Suppressor of cytokine signali ...... diated autoimmune destruction.
@nl
prefLabel
Suppressor of cytokine signali ...... diated autoimmune destruction.
@en
Suppressor of cytokine signali ...... diated autoimmune destruction.
@nl
P2093
P1476
Suppressor of cytokine signali ...... ediated autoimmune destruction
@en
P2093
Helen E Thomas
Janette Allison
Nadine L Dudek
Pere Santamaria
Rima Darwiche
Thomas W H Kay
Windy Irawaty
P304
P356
10.4049/JIMMUNOL.172.9.5714
P407
P577
2004-05-01T00:00:00Z