Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B.
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Purification of carboxypeptidase B from human pancreasThe evolution of insulin glargine and its continuing contribution to diabetes careHigher molecular weight forms of immunoreactive somatostatin in mouse hypothalamic extracts: evidence of processing in vitroProduction of recombinant human proinsulin in the milk of transgenic mice.Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: demonstration of cleavage within clathrin-coated (pro)secretory vesicles.Multiple forms of gastroenteropancreatic hormones.Biochemical and clinical implications of proinsulin conversion intermediates.Adventures with insulin in the islets of LangerhansDonald F. Steiner MD, 1930-2014: discoverer of proinsulin.Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagonSpecificity of prohormone convertase endoproteolysis of progastrin in AtT-20 cellsThree mutations in Zea mays affecting zein accumulation: a comparison of zein polypeptides, in vitro synthesis and processing, mRNA levels, and genomic organization.Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatinsConversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.Soluble insulin analogs combining rapid- and long-acting hypoglycemic properties - From an efficient E. coli expression system to a pharmaceutical formulation.Plasminogen activator of islets of Langerhans: modulation by glucose and correlation with insulin productionBiosynthesis and periplasmic segregation of human proinsulin in Escherichia coli.Semisynthetic human [[3H2]Phe1]proinsulinCharacterization of proinsulin-insulin intermediates in human plasmaConservation of the prohormone convertase gene family in metazoa: analysis of cDNAs encoding a PC3-like protein from hydra.Familial hyperproinsulinemia: partial characterization of circulating proinsulin-like material.Sequential cleavage of proinsulin by human pancreatic kallikrein and a human pancreatic kininaseSecretion and processing of insulin precursors in yeast.A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin.In plant activation: an inducible, hyperexpression platform for recombinant protein production in plants.Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.Human insulin production from a novel mini-proinsulin which has high receptor-binding activity.Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supratherapeutic doses of glargine in subjects with type 1 diabetes.Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin IIProteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules.Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulinBiomimetic synthesis of lispro insulin via a chemically synthesized "mini-proinsulin" prepared by oxime-forming ligation.4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
P2860
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P2860
Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B.
description
1971 nî lūn-bûn
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1971年の論文
@ja
1971年学术文章
@wuu
1971年学术文章
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1971年学术文章
@zh-cn
1971年学术文章
@zh-hans
1971年学术文章
@zh-my
1971年学术文章
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1971年學術文章
@yue
1971年學術文章
@zh-hant
name
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@en
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@nl
type
label
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@en
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@nl
prefLabel
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@en
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@nl
P2093
P1476
Studies on the conversion of p ...... rypsin and carboxypeptidase B.
@en
P2093
Peterson JD
Steiner DF
P304
P407
P577
1971-11-01T00:00:00Z