Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.

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Ontogenic expression of human carboxylesterase-2 and cytochrome P450 3A4 in liver and duodenum: postnatal surge and organ-dependent regulation.

P2860

Q35833727-1F36DACC-D863-44A7-B061-AA7716B2BC15

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Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.

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2013 nî lūn-bûn

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Reduced exposure variability o ...... dualization to CYP3A activity.

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Reduced exposure variability o ...... dualization to CYP3A activity.

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label

Reduced exposure variability o ...... dualization to CYP3A activity.

@en

Reduced exposure variability o ...... dualization to CYP3A activity.

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Reduced exposure variability o ...... dualization to CYP3A activity.

@en

Reduced exposure variability o ...... dualization to CYP3A activity.

@nl

P1476

Reduced exposure variability o ...... dualization to CYP3A activity.

@en

P2093

Berthold Lausecker

http://www.w3.org/2001/XMLSchema#string

Felicitas Stoll

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Johanna Weiss

http://www.w3.org/2001/XMLSchema#string

Torben Thomsen

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P2860

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SLCO1B1 variants and statin-induced myopathy--a genomewide study

Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin.

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.

Cytochrome P450 drug interactions within the HMG-CoA reductase inhibitor class: are they clinically relevant?

Drug metabolism and variability among patients in drug response.

Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.

The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.

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1199-1204

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scholarly article

P356

10.1002/JCPH.161

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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Jürgen Burhenne

Gerd Mikus

Walter E Haefeli

P577

2013-08-31T00:00:00Z

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P698

23939663

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Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.

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P2860

P2860

Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.

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type

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P1433

P1476

P2093

P2860

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P356

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698