Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

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Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

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Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

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2017 nî lūn-bûn

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Reverse Translation in PBPK an ...... to Go Forward With Confidence.

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Creative Commons Attribution-NonCommercial

P2860

Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data.

Impact of physiologically based pharmacokinetic models on regulatory reviews and product labels: Frequent utilization in the field of oncology

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.

A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction.

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.

Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.

Modeling and predicting drug pharmacokinetics in patients with renal impairment.

Physiologically based pharmacokinetics joined with in vitro-in vivo extrapolation of ADME: a marriage under the arch of systems pharmacology.

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scholarly article

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10.1002/CPT.904

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English

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Amin Rostami-Hodjegan

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biomedical investigative technique

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Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

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P2860

P2860

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

description

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type

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P1433

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