Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

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Targeting tumour microenvironment by tyrosine kinase inhibitor.Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.

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Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

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2017 nî lūn-bûn

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Tyrosine kinase inhibition inc ...... apy of acute myeloid leukemia.

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Tyrosine kinase inhibition inc ...... apy of acute myeloid leukemia.

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Tyrosine kinase inhibition inc ...... apy of acute myeloid leukemia.

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Tyrosine kinase inhibition inc ...... apy of acute myeloid leukemia.

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Tyrosine kinase inhibition inc ...... apy of acute myeloid leukemia.

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Tyrosine kinase inhibition inc ...... rapy of acute myeloid leukemia

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E Nößner

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H Leonhardt

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H Polzer

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H R Salih

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P2860

FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro.

Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.

Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

Addition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trial.

Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis.

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leu.2017.257

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10.1038/LEU.2017.257

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immunotherapy

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Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

about

P2860

P2860

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

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