Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.
about
Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical ResearchMTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolProteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sicknessReal-time free cortisol quantification among critically ill children.Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model.Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatinSimultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: application to a bioavailability and protein binding ability study in rat plasma.Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.Characterization of interactions between methoxatin disodium salt and human serum albumin by pressure-assisted capillary electrophoresis/frontal analysis and circular dichroism spectroscopy.The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein bindingEffect of protein binding on unbound atazanavir and darunavir cerebrospinal fluid concentrations.The association between sterilizing activity and drug distribution into tuberculosis lesions.Toxicokinetic Triage for Environmental Chemicals.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Development of oseltamivir phosphonate congeners as anti-influenza agentsIn vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.Antitubercular nitrofuran isoxazolines with improved pharmacokinetic propertiesEntrapment of alpha1-acid glycoprotein in high-performance affinity columns for drug-protein binding studies.Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.Prediction of Drug Penetration in Tuberculosis LesionsFliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium.Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.From known knowns to known unknowns: predicting in vivo drug metabolites.Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug?Probe ADME and test hypotheses: a PATH beyond clearance in vitro-in vivo correlations in early drug discovery.Albumin and α1-acid glycoprotein: old acquaintances.Sample reduction strategies in discovery bioanalysis.Pharmacokinetics of ertapenem in colorectal tissue.Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions.A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid-Phase Extraction System for the Analysis of Protein Binding Samples.An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions.Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins.
P2860
Q27024682-AAAAAAFA-EC7C-482D-A0C6-B59067B503E2Q27643976-A15277F6-11E9-4506-A857-057DD3E4BA7DQ28817181-B6D4054E-E843-4473-8A1A-81E2B0CCB378Q30422470-31F18711-EBE4-4117-AE74-CD0AFD6C3BDFQ30505431-9EB0BA94-6FCD-4F00-B4A8-14C22DF618F7Q30593572-0AAD0DEB-26C5-49C0-94D3-1E0F4C05A319Q30593578-C3083142-A361-4B42-9F7F-F0B6C88A802EQ33797973-FB70DC97-341A-4130-8A1C-3599741A9A76Q34181630-9BA2B02F-BDC8-4A07-8ED4-C514B572D45BQ34241120-56BEE299-A3B1-45B0-8C30-58068C379D98Q34254555-24538EE7-120C-4B3F-83A1-089A1B060408Q35072265-AC3AC89E-B45B-415E-8937-91E320090978Q35103904-507E177D-2122-450D-B24E-28148D06D254Q35172118-C04C3F60-4D1E-4922-B2A5-5D522C8BF1FFQ35186490-572EFAC1-9B94-4768-B2DA-012E02078681Q35404442-903958F7-F9D0-403F-B887-D770C57A5127Q35765601-53C0E17C-F3F7-4E95-932C-7A2D0D3BAE04Q36027800-1B101C35-4698-4903-8E80-0C8D134B96D3Q36204768-28DC7E2B-8B28-4C8C-A5D3-1AA8E7C466C9Q36382214-84E4C68B-F921-49DE-8953-8A8EA05CC8EDQ36558311-C3C21FC1-E74D-4EF8-9FF2-7F2FAA3FCA48Q36637849-C2BDB1BF-0BFF-4780-BAEF-AE9EB80519A8Q36889110-D9B4C1C8-CC0C-4960-9E70-B66FDF439D8CQ37190451-D2701FC4-E576-43E2-ADD6-71D643061EC0Q37265786-BAF25AA2-8B34-4714-8997-A3D1DA5833A2Q37378137-E9654FFA-45DE-4D20-BABD-2EE7ED40A4E7Q37677422-7939C0B1-C003-49A9-87A1-3C006ED2AF67Q37810200-3C68EDAC-40FC-474C-BC1B-A0F456FE5A54Q37884058-E8E44608-D6E3-4756-AC9B-6A4445EDAC1EQ38017309-3EC691B6-759D-48EF-AE96-54CC756E57B9Q38102030-2386A578-1D59-47F1-8340-D4BF8DE223C0Q38118994-16D7BF73-F1D9-4A3F-B9DF-EA45F63B661CQ38479091-9948470E-A9DD-4974-BF5C-62BE6F42E217Q38549232-1F3BFF14-B524-4F31-AB84-6F08FF519CA1Q38619965-32B9ABA7-B47D-4CA8-85DE-0E4F21AEB759Q39477437-8AEA0D39-B655-4DD4-933F-6E8E35AF0F79Q39730914-8E56FAC7-93E1-47A0-9AE6-2378973805BBQ39977756-94FEEF64-071D-4131-AC6D-48DC3EDCD56DQ40207908-72A3A949-98ED-42AA-8520-41DC7F222B3DQ40695320-B805CF41-4EBE-4616-926F-43F88B0F6C0D
P2860
Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Validation of a rapid equilibr ...... ent of plasma protein binding.
@en
Validation of a rapid equilibr ...... ent of plasma protein binding.
@nl
type
label
Validation of a rapid equilibr ...... ent of plasma protein binding.
@en
Validation of a rapid equilibr ...... ent of plasma protein binding.
@nl
prefLabel
Validation of a rapid equilibr ...... ent of plasma protein binding.
@en
Validation of a rapid equilibr ...... ent of plasma protein binding.
@nl
P2093
P356
P1476
Validation of a rapid equilibr ...... ent of plasma protein binding.
@en
P2093
Bindi Sohal
Gareth Williams
Rachel Jones
P304
P356
10.1002/JPS.21317
P407
P577
2008-10-01T00:00:00Z