Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.
about
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNANonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reactionIn situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiationMismatch repair proteins collaborate with methyltransferases in the repair of O(6)-methylguanineMethyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coliInhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli.The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferaseA second DNA methyltransferase repair enzyme in Escherichia coli.Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosoureaLoss of an apurinic/apyrimidinic site endonuclease increases the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine to Escherichia coli.Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse.Adaptive response of Micrococcus luteus to alkylating chemicals.Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladeninesChemical adaptation of M. luteus induces repair functions for O-alkylated DNA pyrimidines.Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6-methylguanineActive site amino acid sequence of the bovine O6-methylguanine-DNA methyltransferase.Bacillus subtilis ada operon encodes two DNA alkyltransferases.Pharmacological inhibition of caspase-8 limits lung tumour outgrowth.New method for gene disruption in Salmonella typhimurium: construction and characterization of an ada-deletion derivative of Salmonella typhimurium TA1535.Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferaseCharacterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNAMultiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agentsInduction of specific Escherichia coli genes by sublethal treatments with alkylating agentsBacillus subtilis mutants deficient in the adaptive response to simple alkylating agents.Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.Adaptive resynthesis of O6-methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair.Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.Mutagenesis, by methylating and ethylating agents, in mutH, mutL, mutS, and uvrD mutants of Salmonella typhimurium LT2.Induction of transversion mutations in Escherichia coli by N-methyl-N'-nitro-N-nitrosoguanidine is SOS dependentO6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli.Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine.Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy.Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.Inducible repair of phosphotriesters in Escherichia coli.Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repairuvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.
P2860
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P2860
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年学术文章
@wuu
1979年学术文章
@zh
1979年学术文章
@zh-cn
1979年学术文章
@zh-hans
1979年学术文章
@zh-my
1979年学术文章
@zh-sg
1979年學術文章
@yue
1979年學術文章
@zh-hant
name
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@en
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@nl
type
label
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@en
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@nl
prefLabel
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@en
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@nl
P2860
P356
P1433
P1476
Adaptive response to alkylatin ...... methylguanine residues in DNA.
@en
P2093
P2860
P2888
P356
10.1038/280076A0
P407
P577
1979-07-01T00:00:00Z
P6179
1016045836