about
Functional characterization of CaVα2δ mutations associated with sudden cardiac deathAire regulates negative selection of organ-specific T cellsCutting edge: genetic characterization of IFN-producing killer dendritic cells.Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes.The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-A(k) NOD miceGenetic lesions in T-cell tolerance and thresholds for autoimmunity.Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus.Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Antagonism between Nur77 and glucocorticoid receptor for control of transcription.Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity.Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice.IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells.An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry.High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies.The Importance of Dendritic Cells in Maintaining Immune Tolerance.An orthologous non-MHC locus in rats and mice is linked to CD4(+) and CD8(+) T-cell proportion.MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs.NK Cell Proportion and Number Are Influenced by Genetic Loci on Chromosomes 8, 9, and 17.Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12.Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetesSpecific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells.Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.The mouse idd2 locus is linked to the proportion of immunoregulatory double-negative T cells, a trait associated with autoimmune diabetes resistance.The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7.T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form.The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility.Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45.BIM determines the number of merocytic dendritic cells, a cell type that breaks immune tolerance.TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death.A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice
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description
hulumtuese
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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Sylvie Lesage
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P106
P21
P31
P496
0000-0002-0968-2795