A human beta-spectrin gene promoter directs high level expression in erythroid but not muscle or neural cells.
about
Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteinsSubstitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceA zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblastsSequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin gene.A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes.GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.Variegated expression from the murine band 3 (AE1) promoter in transgenic mice is associated with mRNA transcript initiation at upstream start sites and can be suppressed by the addition of the chicken beta-globin 5' HS4 insulator element.An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genesThe roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia.The role of p22 NF-E4 in human globin gene switching.p73 plays a role in erythroid differentiation through GATA1 induction.Altered intracellular purine nucleotides in gamma-irradiated red blood cell concentrates.ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene.A minimal ankyrin promoter linked to a human gamma-globin gene demonstrates erythroid specific copy number dependent expression with minimal position or enhancer dependence in transgenic mice.Erythrocyte Ankyrin Promoter Mutations Associated with Recessive Hereditary Spherocytosis Cause Significant Abnormalities in Ankyrin Expression
P2860
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P2860
A human beta-spectrin gene promoter directs high level expression in erythroid but not muscle or neural cells.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@en
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@nl
type
label
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@en
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@nl
prefLabel
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@en
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@nl
P2093
P2860
P356
P1476
A human beta-spectrin gene pro ...... ut not muscle or neural cells.
@en
P2093
Gallagher PG
Garrett LJ
Sabatino DE
P2860
P304
P356
10.1074/JBC.274.10.6062
P407
P577
1999-03-01T00:00:00Z