Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

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Glycerophosphatidylcholine PC(36:1) absence and 3'-phosphoadenylate (pAp) accumulation are hallmarks of the human glioma metabolome IDH1 is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment

P2860

Q57041874-085ADB69-D98E-4DE9-A77B-37264C9BE908 Q58738690-DE975A08-1154-4CB8-B684-C84FA9FBA68F

P2860

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

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http://www.wikidata.org/entity/Q47989563

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

@wuu

2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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name

Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

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Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

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type

Item

label

Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

@en

Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

@nl

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Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

@en

Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

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P1476

Adaptive Evolution of the GDH2 ...... Induced Metabolic Liabilities.

@en

P2093

Austin B Carpenter

http://www.w3.org/2001/XMLSchema#string

Bill H Diplas

http://www.w3.org/2001/XMLSchema#string

Brian O Ingram

http://www.w3.org/2001/XMLSchema#string

Casey J Moure

http://www.w3.org/2001/XMLSchema#string

Christopher J Pirozzi

http://www.w3.org/2001/XMLSchema#string

Edward D Karoly

http://www.w3.org/2001/XMLSchema#string

Hai Yan

http://www.w3.org/2001/XMLSchema#string

Ivan Spasojevic

http://www.w3.org/2001/XMLSchema#string

Landon J Hansen

http://www.w3.org/2001/XMLSchema#string

Matthew S Waitkus

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P2860

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function

Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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36-50

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scholarly article

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10.1158/0008-5472.CAN-17-1352

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Darell D. Bigner

Henry Seth Friedman

Roger E McLendon

P577

2017-11-02T00:00:00Z

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P698

29097607

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P932

5754242

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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

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P2860

P2860

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

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type

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P1433

P1476

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P1476

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