Concomitant oral and intravenous pharmacokinetics of dabrafenib, a BRAF inhibitor, in patients with BRAF V600 mutation-positive solid tumors.
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Simple and cost-effective liquid chromatography-mass spectrometry method to measure dabrafenib quantitatively and six metabolites semi-quantitatively in human plasmaConcomitant oral and intravenous pharmacokinetics of trametinib, a MEK inhibitor, in subjects with solid tumoursApproaches to intravenous clinical pharmacokinetics: Recent developments with isotopic microtracers.Future of combination therapy with dabrafenib and trametinib in metastatic melanoma.A systematic analysis of physicochemical and ADME properties of all small molecule kinase inhibitors approved by US FDA from January 2001 to October 2015.Dabrafenib plus Trametinib: a Review in Advanced Melanoma with a BRAF (V600) Mutation.Dabrafenib for the treatment of melanoma.Adding value through accelerator mass spectrometry-enabled first in human studies.Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics.The synthesis of [(14) C]AZD5122. Incorporation of an IV (14) C-microtracer dose into a first in human study to determine the absolute oral bioavailability of AZD5122.Population pharmacokinetics of dabrafenib, a BRAF inhibitor: effect of dose, time, covariates, and relationship with its metabolites.
P2860
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P2860
Concomitant oral and intravenous pharmacokinetics of dabrafenib, a BRAF inhibitor, in patients with BRAF V600 mutation-positive solid tumors.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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name
Concomitant oral and intraveno ...... utation-positive solid tumors.
@en
Concomitant oral and intraveno ...... utation-positive solid tumors.
@nl
type
label
Concomitant oral and intraveno ...... utation-positive solid tumors.
@en
Concomitant oral and intraveno ...... utation-positive solid tumors.
@nl
prefLabel
Concomitant oral and intraveno ...... utation-positive solid tumors.
@en
Concomitant oral and intraveno ...... utation-positive solid tumors.
@nl
P2093
P2860
P356
P1476
Concomitant oral and intraveno ...... utation-positive solid tumors.
@en
P2093
Cathrine L Denton
Daniele Ouellet
Elisabeth Minthorn
Graeme C Young
Jeffrey Botbyl
Lauren E Richards-Peterson
Royce A Morrison
Samuel C Blackman
Stanley W Carson
P2860
P304
P356
10.1002/JCPH.127
P577
2013-07-12T00:00:00Z