An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
about
Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated regionA phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancerRegulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifenGenome-wide identification of DNaseI hypersensitive sites using active chromatin sequence librariesUpdate on HER-2 as a target for cancer therapy: the ERBB2 promoter and its exploitation for cancer treatmentInverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer.Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complexCofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer.Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cellsNegative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancerZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cellsFulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancyBCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinibMechanisms of resistance to endocrine therapy in breast cancer: focus on signaling pathways, miRNAs and genetically based resistance.The ERBB3 receptor in cancer and cancer gene therapyNuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors.Afatinib in the treatment of breast cancer.Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.p53-dependent downregulation of metastasis-associated laminin receptor.Cloning and characterization of the human beta4-integrin gene promoter and enhancers.Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4.Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells.Antihormone induced compensatory signalling in breast cancer: an adverse event in the development of endocrine resistance.
P2860
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P2860
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@en
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@nl
type
label
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@en
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@nl
prefLabel
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@en
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@nl
P356
P1433
P1476
An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression.
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1201368
P407
P577
1997-07-01T00:00:00Z