Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
about
Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp MiceDysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp miceProximal tubular phosphate reabsorption: molecular mechanismsFGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationHomozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceRole of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemiaAmelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null miceA Genetic Murine Model of Endolymphatic Hydrops: The Phex Mouse.Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice.Essential role of RSK2 in c-Fos-dependent osteosarcoma development.The molecular background to hypophosphataemic rickets.Multiple functions of Osterix are required for bone growth and homeostasis in postnatal miceThe changing face of hypophosphatemic disorders in the FGF-23 eraCooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblastsHigh bone mineral apparent density in children with X-linked hypophosphatemia.Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'.Mechanism by which MLO-A5 late osteoblasts/early osteocytes mineralize in culture: similarities with mineralization of lamellar bone.Mechanosensation and Transduction in Osteocytes.Molecular characterisation of the Hyp deletion and an improved assay for its detection.Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models.Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage ThicknessFGF23, hypophosphatemia, and rickets: has phosphatonin been found?Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets.A clinical and molecular genetic study of hypophosphatemic rickets in children.Identification of osteocyte-selective proteinsFGF23 production by osteocytes.Fibroblast growth factor 23 and bone mineralisation.Pathogenic role of Fgf23 in Dmp1-null mice.Dosage effect of a Phex mutation in a murine model of X-linked hypophosphatemia.The osteocyte: an endocrine cell ... and more.The expanding family of hypophosphatemic syndromes.Hypophosphatemia and growth.Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.Genetic diseases of renal phosphate handling.Skin fibroblasts from spermine synthase-deficient hemizygous gyro male (Gy/Y) mice overproduce spermidine and exhibit increased resistance to oxidative stress but decreased resistance to UV irradiation.
P2860
Q24540520-90655B40-226F-43AD-A028-072A25195D01Q27343138-B2D90018-5925-4D35-A33B-EF89DAF33BE9Q27345068-4AFD40A4-78E4-4FD3-AEBE-43CDF2C5F378Q28140211-6B653E40-B6F5-42E1-99B6-ED762D73E698Q28177435-AF35266E-552D-4E16-8BEE-1458D1069592Q28507303-4DD464A9-F47C-413E-AEA1-F7BAAB61BABDQ28511009-941AB89E-8A53-4A87-8148-F6A6B39CDFC0Q28593754-FCDB914F-C17D-4C27-8781-8E84B84516E2Q30428653-7A542643-58D9-41F5-ADA2-8C49B3C54273Q30484125-6D6FB177-3325-41A3-9475-1CBF3876AD64Q33591785-06E146A4-7028-43DD-8E1F-CC4BA10664BEQ33634310-050430D2-73F5-4469-80B4-2C6C06FB322EQ33808604-FE1D2768-D3DE-4D18-B9AE-5884723CD4DBQ33842091-91C09D74-6B89-48E9-B0D6-BBD49BDC0122Q34010727-200FB59B-6710-43D0-BFCE-BD1616970229Q34059112-E3C306A5-0B9A-4A1C-9D98-980D19F5D248Q34221238-53FCBDD4-E581-4AD1-A853-C01FFC2886DCQ34251323-CB79533E-5F74-4D8B-9EB5-703AE9E63303Q34579718-7337DA11-AF16-4C2A-AD0C-FB711E94F60FQ34718202-649462D1-EB76-4FFF-9A2C-E611FB7226E7Q35218561-774331E5-EF5F-438B-B70E-E16DFE4F035AQ35645894-E89C8746-5417-467C-8FA8-7E5CB2199268Q35741903-17053D08-0350-40DF-800C-1E5587CDD15CQ35754257-3E9BA808-211C-4B52-BD4C-DCC5FEDDBBD0Q35755137-9F16E1E1-C3A6-4ED8-B2F9-DE9A7B70172BQ35858719-5344FFA9-D7EA-4E57-9357-0CD69B33B643Q35921407-E8691189-61EB-4F30-BE83-78F2E313CF17Q35975734-6FF744B2-72EA-40E8-8F84-3B963439123EQ36213739-A44EAA34-11F3-415A-8F22-1FEAE201D1CEQ36453030-B9A36BE7-A9BA-4A92-B661-E7F381DAC791Q36639867-28C665F1-508B-4E1A-95C2-36F5634B45DBQ36756061-0600919D-665C-41F2-8542-879F4E94BB25Q36846110-E7C89C86-220E-4270-9F4E-34DD233EBF5EQ37092161-0E31905A-9C76-4D5F-8341-6B494CED02E9Q37203605-EC2C77C7-E835-41F0-BEDE-3ADAFBA641C2Q37968185-33909819-F93D-45B6-98DC-CE56D10D4247Q38062345-9D0890DD-CCE0-42A9-8AB0-8FD81422E847Q38081019-D1524985-3725-4B9C-A688-4E817334AD1FQ38244118-8873095A-13ED-4AE5-B480-752EBCE3308FQ38306531-718624E5-B630-42C8-9D7F-5BD2B45E190E
P2860
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@en
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@nl
type
label
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@en
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@nl
prefLabel
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@en
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@nl
P2093
P2860
P50
P356
P1476
Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia.
@en
P2093
P2860
P304
P356
10.1093/HMG/6.2.165
P577
1997-02-01T00:00:00Z