Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.
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Mechanisms of Hippo pathway regulationA critical role for NF2 and the Hippo pathway in branching morphogenesisCurrent understanding concerning intestinal stem cellsDrug Discovery via Human-Derived Stem Cell OrganoidsEGF receptor ligands: recent advancesLong-Term Culture of Intestinal Cell Progenitors: An Overview of Their Development, Application, and Associated TechnologiesTargeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer TherapyThe Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and WartsIntestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth InfectionDrosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gutThe Hippo pathway in tissue homeostasis and regeneration.TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial CellsThe Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.YAP Induces Human Naive PluripotencyLawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation.Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assayPaneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma.RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.The Hippo signaling pathway provides novel anti-cancer drug targets.Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.Investigating cell therapy for inflammatory bowel disease.The Hippo pathway in intestinal regeneration and disease.YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage.Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells.YAP/TAZ at the Roots of Cancer.MicroRNAs and Inflammation in Colorectal Cancer.Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies.Crosstalk between Hippo signalling and miRNAs in tumour progression.The EMT spectrum and therapeutic opportunities.Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches.Wnt target genes and where to find them.R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma.SNORA21 - An Oncogenic Small Nucleolar RNA, with a Prognostic Biomarker Potential in Human Colorectal Cancer.Role of Src family kinases in regulation of intestinal epithelial homeostasis.Knockdown of a DIS3L2 promoter upstream long noncoding RNA (AC105461.1) enhances colorectal cancer stem cell properties in vitro by down-regulating DIS3L2.Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models.A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.
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P2860
Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Yap-dependent reprogramming of Lgr5
@nl
Yap-dependent reprogramming of ...... tinal regeneration and cancer.
@en
type
label
Yap-dependent reprogramming of Lgr5
@nl
Yap-dependent reprogramming of ...... tinal regeneration and cancer.
@en
prefLabel
Yap-dependent reprogramming of Lgr5
@nl
Yap-dependent reprogramming of ...... tinal regeneration and cancer.
@en
P2093
P2860
P356
P1433
P1476
Yap-dependent reprogramming of ...... tinal regeneration and cancer.
@en
P2093
Alex Gregorieff
Jeffrey L Wrana
Mohammad R Inanlou
Yuliya Khomchuk
P2860
P2888
P304
P356
10.1038/NATURE15382
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P577
2015-10-21T00:00:00Z
P6179
1017213436