Alleles of the APC gene: an attenuated form of familial polyposis.
about
Attenuated APC alleles produce functional protein from internal translation initiation.Genotype-phenotype correlations in attenuated adenomatous polyposis coli.Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc geneA targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumorsMUTYH the base excision repair gene family member associated with colorectal cancer polyposisColorectal cancer and genetic alterations in the Wnt pathwayRepurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposisVariable phenotype of familial adenomatous polyposis in pedigrees with 3' mutation in the APC gene.Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systemsThe UMD-APC database, a model of nation-wide knowledge base: update with data from 3,581 variations.Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72.Colorectal cancer: molecules and populations.Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome.Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC geneMicrosatellite instability in early onset and familial colorectal cancer.Familial adenomatous polyposis in a 5 year old child: a clinical, pathological, and molecular genetic studyPresymptomatic diagnosis in Portuguese FAP families using intragenic RFLPs and (CA)n flanking markers by fluorescence based semiautomated DNA analysis.Germline Missense Changes in the APC Gene and Their Relationship to DiseaseAntagonism of WT1 activity by protein self-association.Genetic susceptibility to non-polyposis colorectal cancer.Clinical challenges in management of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer.Genetic testing and counseling for hereditary forms of colorectal cancer.APC and intestinal carcinogenesis. Insights from animal models.Hereditary Non-Polyposis Colorectal Cancer: the rise and fall of a confusing term.Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.Hereditary colorectal cancer: risk assessment and management.Attenuated familial adenomatous polyposis manifests as autosomal dominant late-onset colorectal cancer.Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.Novel germline APC gene mutation in a large familial adenomatous polyposis kindred displaying variable phenotypes.Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome.p53 gene mutation: software and database.APC gene: database of germline and somatic mutations in human tumors and cell lines.Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.Challenge in the differentiation between attenuated familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer: case report with review of the literature.Review article: genetic testing and counselling for hereditary colorectal cancer.Genetic testing for colon cancer: joint statement of the American College of Medical Genetics and American Society of Human Genetics. Joint Test and Technology Transfer Committee Working Group.
P2860
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P2860
Alleles of the APC gene: an attenuated form of familial polyposis.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Alleles of the APC gene: an attenuated form of familial polyposis.
@en
Alleles of the APC gene: an attenuated form of familial polyposis.
@nl
type
label
Alleles of the APC gene: an attenuated form of familial polyposis.
@en
Alleles of the APC gene: an attenuated form of familial polyposis.
@nl
prefLabel
Alleles of the APC gene: an attenuated form of familial polyposis.
@en
Alleles of the APC gene: an attenuated form of familial polyposis.
@nl
P2093
P1433
P1476
Alleles of the APC gene: an attenuated form of familial polyposis.
@en
P2093
Olschwang S
Robertson M
Samowitz W
Thliveris A
P304
P356
10.1016/0092-8674(93)90538-2
P407
P577
1993-12-01T00:00:00Z