Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity.
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Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injuryCostimulation of N-methyl-D-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes.Neuroprotective effects of pyruvate following NMDA-mediated excitotoxic insults in hippocampal slicesPyruvate carboxylation in neurons.The role of astroglia in neuroprotectionPyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cellsL-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade.Robust neuroprotective effects of 2-((2-oxopropanoyl)oxy)-4-(trifluoromethyl)benzoic acid (OPTBA), a HTB/pyruvate ester, in the postischemic rat brain.Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic TreatmentsPyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation.Multifunctional role of astrocytes as gatekeepers of neuronal energy supplyDegeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates.Serum or target deprivation-induced neuronal death causes oxidative neuronal accumulation of Zn2+ and loss of NAD+.Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria.Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes.Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro.GABA is toxic for mouse striatal neurones through a transporter-mediated process.Glutamate uptake inhibitor L-trans-pyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitochondrial toxin 3-nitropropionate: involvement of mitochondrial reducing activity and ATP production.Neuroprotective profile of pyruvate against ethanol-induced neurodegeneration in developing mice brain.2-Deoxyglucose and NMDA inhibit protein synthesis in neurons and regulate phosphorylation of elongation factor-2 by distinct mechanisms.Pyruvate and creatine prevent oxidative stress and behavioral alterations caused by phenylalanine administration into hippocampus of rats.Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism.Creatine and pyruvate prevent the alterations caused by tyrosine on parameters of oxidative stress and enzyme activities of phosphoryltransfer network in cerebral cortex of Wistar rats.Energy substrates protect hippocampus against endogenous glutamate-mediated neurodegeneration in awake rats.Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation.
P2860
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P2860
Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@en
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@nl
type
label
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@en
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@nl
prefLabel
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@en
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@nl
P2093
P2860
P1476
Pyruvate and lactate protect s ...... partate-induced neurotoxicity.
@en
P2093
P2860
P304
P356
10.1046/J.1460-9568.1999.00745.X
P407
P577
1999-09-01T00:00:00Z