A common mechanism for CFTR potentiators.

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Structural mechanisms of CFTR function and dysfunction.Ion Channel Modulators in Cystic Fibrosis Identification and Characterization of Novel CFTR Potentiators

P2860

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A common mechanism for CFTR potentiators.

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http://www.wikidata.org/entity/Q48111581

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2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年学术文章

@wuu

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

@zh

2017年學術文章

@zh-hant

name

A common mechanism for CFTR potentiators.

@en

A common mechanism for CFTR potentiators.

@nl

type

Item

label

A common mechanism for CFTR potentiators.

@en

A common mechanism for CFTR potentiators.

@nl

prefLabel

A common mechanism for CFTR potentiators.

@en

A common mechanism for CFTR potentiators.

@nl

P1476

A common mechanism for CFTR potentiators.

@en

P2093

Yoshiro Sohma

http://www.w3.org/2001/XMLSchema#string

P2860

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

Cystic fibrosis

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain.

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Molecular pharmacology of the CFTR Cl- channel.

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR).

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.

P304

1105-1118

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P31

scholarly article

P356

10.1085/JGP.201711886

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P433

http://www.w3.org/2001/XMLSchema#string

P478

149

http://www.w3.org/2001/XMLSchema#string

P50

Tzyh-Chang Hwang

Han-I Yeh

Katja Conrath

P577

2017-10-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

29079713

http://www.w3.org/2001/XMLSchema#string

P932

5715911

http://www.w3.org/2001/XMLSchema#string

A common mechanism for CFTR potentiators.

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P2860

P2860

A common mechanism for CFTR potentiators.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P932