Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.
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Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.Genetics of type 1 diabetes mellitusGenetic analysis of type 1 diabetes using whole genome approachesTests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).Estimation of synteny conservation and genome compaction between pufferfish (Fugu) and humanComparison of three methods for single nucleotide polymorphism typing for DNA bank studies: sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE).Type 1 1/2 diabetes: myth or reality?Genetics and pathogenesis of type 1 diabetes: prospects for prevention and interventionEarly onset of diabetes mellitus associated with the mitochondrial DNA T14709C point mutation: patient report and literature review.Global haplotype diversity in the human insulin gene region.Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.Both polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD miceEvidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6.Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.Molecular aspects of type 1 diabetesRegulatory polymorphisms underlying complex disease traits.Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27Large-scale temporal gene expression mapping of central nervous system development.Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.The effect of parental imprinting on the INS-IGF2 locus of Korean type I diabetic patientsPolymorphism of the insulin gene is associated with increased prostate cancer risk.Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West.Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review.The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Novel biomarkers in type 1 diabetes.Type 1 diabetes in the BB rat: a polygenic diseaseAssociation of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents.No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population.Complex recombination events at the hypermutable minisatellite CEB1 (D2S90).Type 1 diabetes: etiology, immunology, and therapeutic strategies.Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals.
P2860
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P2860
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@en
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@nl
type
label
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@en
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@nl
prefLabel
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@en
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@nl
P2093
P2860
P356
P1433
P1476
Susceptibility to insulin depe ...... ulin gene and associated VNTR.
@en
P2093
P2860
P2888
P304
P356
10.1038/NG0793-305
P407
P577
1993-07-01T00:00:00Z