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Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptorsDespite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranesDiscovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12)Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat.Age and adjustment to night work.Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradationSynthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptorThe basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections.Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol.Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice.Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation.Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.[(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor.Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells.Melatonin receptor genes.Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits.Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking.Important amino acids for the function of the human MT1 melatonin receptor.Adenosine A1 receptor-dependent G-protein activity in the rat brain during prolonged wakefulness.Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor.Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes.The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor.Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.Exposure to a 50-hz magnetic field induces a circadian rhythm in 6-hydroxymelatonin sulfate excretion in mice.Neuroanatomical mapping of juvenile rat brain regions with prominent basal signal in [(35)S]GTPgammaS autoradiography.Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE).Guanosine 5'-(gamma-[35S]thio)triphosphate autoradiography allows selective detection of histamine H3 receptor-dependent G protein activation in rat brain tissue sections.Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.Selective detection of adenosine A1 receptor-dependent G-protein activity in basal and stimulated conditions of rat brain [35S]guanosine 5'-(gamma-thio)triphosphate autoradiography.Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry.Functional autoradiography shows unaltered cannabinoid CB1 receptor signalling in hippocampus and cortex of APP/PS1 transgenic mice.Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography.
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jarmo T Laitinen
@ast
Jarmo T Laitinen
@en
Jarmo T Laitinen
@es
Jarmo T Laitinen
@nl
Jarmo T Laitinen
@sl
type
label
Jarmo T Laitinen
@ast
Jarmo T Laitinen
@en
Jarmo T Laitinen
@es
Jarmo T Laitinen
@nl
Jarmo T Laitinen
@sl
prefLabel
Jarmo T Laitinen
@ast
Jarmo T Laitinen
@en
Jarmo T Laitinen
@es
Jarmo T Laitinen
@nl
Jarmo T Laitinen
@sl
P106
P21
P2798
P31
P496
0000-0002-9490-3686
P569
2000-01-01T00:00:00Z