Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.
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Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA DysregulationBioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connectionThe two-hit hypothesis for neuroinflammation: role of exogenous ATP in modulating inflammation in the brainP2X ion channel receptors and inflammationP2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferationCritical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery.Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in miceThe P2 receptor antagonist PPADS supports recovery from experimental stroke in vivoIn vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brainBrilliant blue G attenuates lipopolysaccharide-mediated microglial activation and inflammationAscorbic acid prevents blood-brain barrier disruption and sensory deficit caused by sustained compression of primary somatosensory cortexNTPDase1 governs P2X7-dependent functions in murine macrophagesCOL-3, a chemically modified tetracycline, inhibits lipopolysaccharide-induced microglia activation and cytokine expression in the brain.P2Y receptors in Alzheimer's disease.P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticusEstrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathyATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation.Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's DiseaseNucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activationPharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease.P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitriteRelease of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits.Microglial P2 Purinergic Receptor and Immunomodulatory Gene Transcripts Vary By Region, Sex, and Age in the Healthy Mouse CNS.Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signalingSleep and immune function: glial contributions and consequences of agingMicroglia during development and aging.P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats.Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation.Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease.Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.Neuroprotective roles of the P2Y(2) receptor.Classical and unconventional pathways of vesicular release in microglia.P2X(7) receptors in cerebral ischemiaPharmacological properties of the rhesus macaque monkey P2X7 receptor.Purinergic signaling and the functioning of the nervous system cells.P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells.
P2860
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P2860
Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Modulation of the purinergic P ...... onal damage in inflamed brain.
@en
Modulation of the purinergic P ...... onal damage in inflamed brain.
@nl
type
label
Modulation of the purinergic P ...... onal damage in inflamed brain.
@en
Modulation of the purinergic P ...... onal damage in inflamed brain.
@nl
prefLabel
Modulation of the purinergic P ...... onal damage in inflamed brain.
@en
Modulation of the purinergic P ...... onal damage in inflamed brain.
@nl
P2093
P1476
Modulation of the purinergic P ...... ronal damage in inflamed brain
@en
P2093
Hyun B Choi
James G McLarnon
Seung U Kim
P304
P356
10.1523/JNEUROSCI.5417-06.2007
P407
P577
2007-05-01T00:00:00Z