The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.
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Protective and damaging effects of stress mediators: central role of the brainBreaking boundaries-coagulation and fibrinolysis at the neurovascular interfaceProteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson diseaseAdvances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative DiseasesBapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapyKey role of tissue plasminogen activator in neurovascular couplingMultiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosisNeurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersFibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's diseaseReducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Therapeutic potential of resveratrol in Alzheimer's diseaseMicroglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation.Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.Targeting Abeta and tau in Alzheimer's disease, an early interim reportKnockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling.Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathologyCholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disordersA monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variablesCoordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system.Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease.Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders.Transcriptomics Profiling of Alzheimer's Disease Reveal Neurovascular Defects, Altered Amyloid-β Homeostasis, and Deregulated Expression of Long Noncoding RNAsLithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling.The TGF-beta1/upstream stimulatory factor-regulated PAI-1 gene: potential involvement and a therapeutic target in Alzheimer's diseaseTissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice.Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemiaEnhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators.Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease.Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease.Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.The AbetaCs of Abeta-cleaving proteases.Zinc-triggered induction of tissue plasminogen activator and plasminogen in endothelial cells and pericytes.Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism.
P2860
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P2860
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The tissue plasminogen activat ...... eta-induced neurodegeneration.
@en
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta
@nl
type
label
The tissue plasminogen activat ...... eta-induced neurodegeneration.
@en
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta
@nl
prefLabel
The tissue plasminogen activat ...... eta-induced neurodegeneration.
@en
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta
@nl
P1476
The tissue plasminogen activat ...... beta-induced neurodegeneration
@en
P2093
Jerry P Melchor
Robert Pawlak
P304
P356
10.1523/JNEUROSCI.23-26-08867.2003
P407
P577
2003-10-01T00:00:00Z