Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.
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The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseControl of cellular Bcl-xL levels by deamidation-regulated degradationThe homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tanglesAnalysis of isoaspartate in peptides by electrospray tandem mass spectrometry.Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation.Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.A potential biomarker in the cord blood of preterm infants who develop retinopathy of prematurity.Tissue transglutaminase-mediated glutamine deamidation of beta-amyloid peptide increases peptide solubility, whereas enzymatic cross-linking and peptide fragmentation may serve as molecular triggers for rapid peptide aggregationStructure and pathology of tau protein in Alzheimer disease.Use of site-directed mutagenesis to model the effects of spontaneous deamidation on the immunogenicity of Bacillus anthracis protective antigenIdentification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetesStable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formationCeruloplasmin functional changes in Parkinson's disease-cerebrospinal fluidThe synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tauTransgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.Lessons from two prevalent amyloidoses-what amylin and Aβ have in commonQuantification of isotopically overlapping deamidated and 18o-labeled peptides using isotopic envelope mixture modelingExtensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signaling.Protein truncation as a common denominator of human neurodegenerative foldopathies.Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated formsMolecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.Are tau aggregates toxic or protective in tauopathies?CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE.Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR: insight into intrinsically disordered proteins.Effect of deamidation on folding of ribonuclease A.Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency.Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease.Proteolysis of non-phosphorylated and phosphorylated tau by thrombin.
P2860
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P2860
Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@en
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@nl
type
label
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@en
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@nl
prefLabel
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@en
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@nl
P2093
P2860
P356
P1476
Deamidation and isoaspartate f ...... otubule-binding domain of tau.
@en
P2093
P2860
P304
P356
10.1074/JBC.274.11.7368
P407
P577
1999-03-01T00:00:00Z