Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum.
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Molecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine-pyrimethamine in TanzaniaSubmicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western KenyaTransformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanilGenetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial.Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations.Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern TanzaniaKinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination.Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum.Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae.Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali.Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study.Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.Red blood cell polymorphism and susceptibility to Plasmodium vivax.Prevalence of anti-malarial resistance genes in Dakar, Senegal from 2013 to 2014.Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.Plasmodium falciparum: correlation of in vivo resistance to chloroquine and antifolates with genetic polymorphisms in isolates from the south of Lao PDR.Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates.A community-randomized evaluation of the effect of intermittent preventive treatment in infants on antimalarial drug resistance in southern Tanzania.Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum.Changes in enzyme activity and expression of DHFR of Toxoplasma gondii by antifolates.Defining the role of mutations in Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene using an episomal Plasmodium falciparum transfection system.Inactivation of human immunodeficiency virus type 1 in blood samples stored as high-salt lysates.A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
P2860
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P2860
Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh-hant
name
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@en
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@nl
type
label
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@en
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@nl
prefLabel
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@en
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@nl
P2093
P1476
Point mutations in the dihydro ...... ance in Plasmodium falciparum.
@en
P2093
P304
P356
10.1016/0166-6851(89)90173-4
P577
1989-10-01T00:00:00Z