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A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compoundsHigh-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubulesTrastuzumab emtansine: mechanisms of action and drug resistanceAntibody-DM1 conjugates as cancer therapeutics.Drugs that target dynamic microtubules: a new molecular perspectiveDemonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).Biological considerations and clinical applications of new HER2-targeted agents.The microtubule as a breast cancer target.Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine siteMaytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.Rhazinilam mimics the cellular effects of taxol by different mechanisms of action.Tryprostatin A, a specific and novel inhibitor of microtubule assemblyInteractions of vinblastine and maytansine with tubulin.Dissociation of tubulin assembly-inhibiting and aggregation-promoting activities by a vinblastine derivative.Localization of the vinblastine-binding site on beta-tubulin.
P2860
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P2860
description
1977 nî lūn-bûn
@nan
1977年の論文
@ja
1977年学术文章
@wuu
1977年学术文章
@zh-cn
1977年学术文章
@zh-hans
1977年学术文章
@zh-my
1977年学术文章
@zh-sg
1977年學術文章
@yue
1977年學術文章
@zh
1977年學術文章
@zh-hant
name
Maytansine binding to the vinblastine sites of tubulin.
@en
Maytansine binding to the vinblastine sites of tubulin.
@nl
type
label
Maytansine binding to the vinblastine sites of tubulin.
@en
Maytansine binding to the vinblastine sites of tubulin.
@nl
prefLabel
Maytansine binding to the vinblastine sites of tubulin.
@en
Maytansine binding to the vinblastine sites of tubulin.
@nl
P2860
P1433
P1476
Maytansine binding to the vinblastine sites of tubulin.
@en
P2093
Bhattacharyya B
P2860
P304
P356
10.1016/0014-5793(77)80075-6
P407
P577
1977-03-01T00:00:00Z