Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
about
Highly conserved non-coding sequences are associated with vertebrate developmentSubfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence3' deletions cause aniridia by preventing PAX6 gene expressionActivation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1The transcription factor LSF: a novel oncogene for hepatocellular carcinomaSox2 and Pou2f1 interact to control lens and olfactory placode developmentTALE transcription factors during early development of the vertebrate brain and eyeSequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergencesCited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesisHedgehog-regulated localization of Vax2 controls eye developmentMutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.Six3 activation of Pax6 expression is essential for mammalian lens induction and specificationConditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup developmentChromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleationVax genes ventralize the embryonic eyeMeis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesisPax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eyeSOX2 is a dose-dependent regulator of retinal neural progenitor competenceIsolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemusThe probability of duplicate gene preservation by subfunctionalizationDisruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.Comparative genomics-based identification and analysis of cis-regulatory elementsSimple, fast, tissue-specific bacterial artificial chromosome transgenesis in Xenopus.Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis.An evolutionary constraint: strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules.Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice.Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cellsPredicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule miningExpression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factorsDepression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary bodyPAX6 haplotypes are associated with high myopia in Han chinese.Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortexAlgebraic distribution of segmental duplication lengths in whole-genome sequence self-alignmentsEvolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene.Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals.DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.Lhx2 regulates a cortex-specific mechanism for barrel formation.Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreasPax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells.
P2860
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P2860
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@en
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@nl
type
label
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@en
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@nl
prefLabel
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@en
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@nl
P2093
P356
P1476
Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity.
@en
P2093
P356
10.1006/DBIO.1998.9128
P407
P577
1999-01-01T00:00:00Z