Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

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Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib

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Q58729853-0DEE3EEC-B64A-4ACA-8F51-668341E2A285

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Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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Establishing a chemical geneti ...... micro-environmental dialogue.

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Establishing a chemical geneti ...... micro-environmental dialogue.

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Establishing a chemical geneti ...... micro-environmental dialogue.

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Establishing a chemical geneti ...... micro-environmental dialogue.

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Establishing a chemical geneti ...... micro-environmental dialogue.

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Establishing a chemical geneti ...... micro-environmental dialogue.

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P1476

Establishing a chemical geneti ...... micro-environmental dialogue.

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P2093

Anna Guastafierro

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Elisa Göckeritz

http://www.w3.org/2001/XMLSchema#string

Floyd Hassenrück

http://www.w3.org/2001/XMLSchema#string

Günter Krause

http://www.w3.org/2001/XMLSchema#string

Lars Neumann

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Maja Pizevska

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Verena Vondey

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P2860

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

Disruption of in vivo Chronic Lymphocytic Leukemia Tumor-Microenvironment Interactions by Ibrutinib--Findings from an Investigator-Initiated Phase II Study

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia.

Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells.

Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.

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scholarly article

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10.1111/BJH.14781

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English

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178

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Michael Hallek

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2017-06-01T00:00:00Z

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28573668

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Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

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P2860

P2860

Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

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P2860

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