Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Advances at the intersection of chemical biology and medicinal chemistry.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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name

Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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P1476

Toward peptide-based inhibitors as therapies for Parkinson's disease

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P2093

Jody M Mason

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P2860

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

Alpha-synuclein in Lewy bodies

The future of peptide-based drugs

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

Amyloid formation from an α-helix peptide bundle is seeded by 3(10)-helix aggregates.

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation.

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

P304

2103-2105

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scholarly article

editorial

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10.4155/FMC.15.139

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David P. Fairlie

Jody M. Mason

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2015-10-29T00:00:00Z

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283324910

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Toward peptide-based inhibitors as therapies for Parkinson's disease.

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P2860

P2860

Toward peptide-based inhibitors as therapies for Parkinson's disease.

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P1476

P2093

P2860

P304

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P698