about
Marine Natural Products as Models to Circumvent Multidrug ResistanceStrategies to Overcome Heparins' Low Oral BioavailabilityCurcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and PerspectivesDevelopment of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrateSulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA.Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase.P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.Synergistic Effects Between Thioxanthones and Oxacillin Against Methicillin-Resistant Staphylococcus aureus.Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenoneQuantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.Xanthone derivatives: new insights in biological activities.Three decades of P-gp inhibitors: skimming through several generations and scaffolds.Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration.A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.Structure-activity relationship studies for multitarget antithrombotic drugs.Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines.Anticancer and cancer preventive compounds from edible marine organisms.The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs.Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.Bromoalkoxyxanthones as promising antitumor agents: synthesis, crystal structure and effect on human tumor cell lines.Antifouling potential of Nature-inspired sulfated compounds.11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic ChemistryPolysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.Inhibition of protein kinase C by synthetic xanthone derivatives.Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.Microbial interaction between a CTXM-15 -producing Escherichia coli and a susceptible Pseudomonas aeruginosa isolated from bronchoalveolar lavage: influence of cefotaxime in the dual-species biofilm formation.An antifouling model from the sea: a review of 25 years of zosteric acid studies.Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy.Sources and Biological Activities of Marine Sulfated Steroids.Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.Potential benefits of a sulfated resveratrol derivative for topical application.Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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E Sousa
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E Sousa
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E Sousa
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E Sousa
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E P Sousa
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Emília P Sousa
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Emília Sousa
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M E Sousa
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M Emília Sousa
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Maria Emília Silva Pereira de Sousa
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Maria Emília Sousa
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Maria Emília de Sousa
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P1053
L-1126-2014
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P1153
56363952500
7004889524
P31
P3829
P3835
maria-emlia-sousa
P496
0000-0002-5397-4672