The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
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Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activityTonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal GangliaIncreases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levelsgamma-Aminobutyric acid transporters in the cat periaqueductal gray: a light and electron microscopic immunocytochemical study.Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research.The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent.The pharmacologic basis of antiepileptic drug action.Basic mechanisms of gabitril (tiagabine) and future potential developments.Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticityClinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs.Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo.Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitroGABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.Tiagabine in anxiety disorders.Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex.Slow wave sleep induced by GABA agonist tiagabine fails to benefit memory consolidation.Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist.Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjectsEnhancement of slow wave sleep: implications for insomniaThe use of magnetoencephalography in the study of psychopharmacology (pharmaco-MEG).Neurophysiologically-informed markers of individual variability and pharmacological manipulation of human cortical gamma.Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.Clobazam, oxcarbazepine, tiagabine, topiramate, and other new antiepileptic drugs.Update on the mechanism of action of antiepileptic drugs.Brain microdialysis of GABA and glutamate: what does it signify?Neuropharmacological and neurobiological relevance of in vivo ¹H-MRS of GABA and glutamate for preclinical drug discovery in mental disordersA PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder.New guidelines for diagnosis and treatment of insomnia.Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels.The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks.The anticonvulsant valproate increases the turnover rate of gamma-aminobutyric acid transporters.Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters.Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke.Substitution therapy for alcoholism: time for a reappraisal?Tiagabine: a novel antiepileptic drug.Effects of acute tiagabine administration on aggressive responses of adult male parolees.Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle.
P2860
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P2860
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@en
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@nl
type
label
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@en
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@nl
prefLabel
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@en
The gamma-aminobutyric acid (G ...... levels of GABA in awake rats.
@nl
P2093
P1476
The gamma-aminobutyric acid (G ...... n levels of GABA in awake rats
@en
P2093
P304
P356
10.1016/0014-2999(92)90748-S
P407
P577
1992-09-01T00:00:00Z