Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. - Wikidata - awgldk - TriplyDB

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

http://www.wikidata.org/entity/Q48444707

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The Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic Nanomachines Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone APP as a Protective Factor in Acute Neuronal Insults.Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.The keystone of Alzheimer pathogenesis might be sought in Aβ physiology Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models.Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.The Role of APP in Structural Spine Plasticity.Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism.Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα.APP-A Novel Player within the Presynaptic Active Zone Proteome.Not just amyloid: physiological functions of the amyloid precursor protein family.Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms.APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins.Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network.Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants.Inhibition of Protease-Activated Receptor 1 Does not Affect Dendritic Homeostasis of Cultured Mouse Dentate Granule Cells.ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease.Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

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Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

http://www.wikidata.org/entity/Q48444707

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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2014年學術文章

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name

Acute function of secreted amy ...... APPsα in synaptic plasticity.

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Acute function of secreted amy ...... APPsα in synaptic plasticity.

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type

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Acute function of secreted amy ...... APPsα in synaptic plasticity.

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Acute function of secreted amy ...... APPsα in synaptic plasticity.

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Acute function of secreted amy ...... APPsα in synaptic plasticity.

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Acute function of secreted amy ...... APPsα in synaptic plasticity.

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Acta Neuropathologica

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Acute function of secreted amy ...... t APPsα in synaptic plasticity

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Andreas Draguhn

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David P Wolfer

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Jakob-Andreas Tschäpe

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Jan-Philipp Mallm

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Lutz Slomianka

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Marc Mercken

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Marianne Borgers

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Martin Korte

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Meike Hick

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Sascha W Weyer

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P2860

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

Roles of the amyloid precursor protein family in the peripheral nervous system

Hippocampal network oscillations in APP/APLP2-deficient mice

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

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