Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.
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Properties and use of botulinum toxin and other microbial neurotoxins in medicineToxigenic clostridiaCrystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron InteractionBotulinum Neurotoxin Is Shielded by NTNHA in an Interlocked ComplexAn assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin.Characterization of neutralizing antibodies and identification of neutralizing epitope mimics on the Clostridium botulinum neurotoxin type A.Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses.Biophysical characterization of the stability of the 150-kilodalton botulinum toxin, the nontoxic component, and the 900-kilodalton botulinum toxin complex species.Purification, potency, and efficacy of the botulinum neurotoxin type A binding domain from Pichia pastoris as a recombinant vaccine candidate.Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.Expression of HC subunits from Clostridium botulinum types C and D and their evaluation as candidate vaccine antigens in mice.The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions.Towards new uses of botulinum toxin as a novel therapeutic toolArchitecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.Assembly and function of the botulinum neurotoxin progenitor complexRecombinant derivatives of botulinum neurotoxin A engineered for trafficking studies and neuronal delivery.Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type AAntibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms.Antigenic structure of Clostridium botulinum type B neurotoxin and its interaction with gangliosides, cerebroside, and free fatty acids.The use of monoclonal antibodies to analyze the structure of Clostridium botulinum type E derivative toxin.Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics.Immunological characterization of papain-induced fragments of Clostridium botulinum type A neurotoxin and interaction of the fragments with brain synaptosomes.Structure and function of Clostridium botulinum toxins.Botulinum type F neurotoxin. Large-scale purification and characterization of its binding to rat cerebrocortical synaptosomes.Bivalent recombinant vaccine for botulinum neurotoxin types A and B based on a polypeptide comprising their effector and translocation domains that is protective against the predominant A and B subtypes.Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones.Clostridium botulinum toxins: nature and preparation for clinical use.Engineering botulinum neurotoxin domains for activation by toxin light chain.Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity
P2860
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P2860
Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh-hant
name
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@en
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@nl
type
label
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@en
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@nl
prefLabel
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@en
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@nl
P2093
P1433
P1476
Inactivation of Clostridium bo ...... stroys toxin-binding activity.
@en
P2093
P356
10.1111/J.1432-1033.1985.TB09070.X
P407
P577
1985-08-01T00:00:00Z