Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans. - Wikidata - awgldk - TriplyDB

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

http://www.wikidata.org/entity/Q48466996

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Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis.Development of targeted therapies for Parkinson's disease and related synucleinopathies N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease.GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding.Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.Pathogenic role of ganglioside metabolism in neurodegenerative diseases.Membrane lipids as therapeutic targets for Parkinson's disease: a possible link between Lewy pathology and membrane lipids.Gangliosides of the Vertebrate Nervous System Lipid glycosylation: a primer for histochemists and cell biologists.Involvement of sphingolipids in ethanol neurotoxicity in the developing brain Enhanced Autophagy Contributes to Protective Effects of GM1 Ganglioside Against Aβ1-42-Induced Neurotoxicity and Cognitive Deficits.Lipid Involvement in Neurodegenerative Diseases of the Motor System: Insights from Lysosomal Storage Diseases.Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.Ganglioside Metabolism and Parkinson's Disease.First total synthesis of ganglioside DSG-A possessing neuritogenic activity.Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson's disease.Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson's Disease.Changes in ganglioside GM1 expression in glaucomic retina

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P2860

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

http://www.wikidata.org/entity/Q48466996

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

@zh-hant

name

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@en

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@nl

type

label

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@en

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@nl

prefLabel

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@en

Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

@nl

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Journal of Neuroscience Research

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Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans.

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Gusheng Wu

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Neil Kulkarni

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Robert W Ledeen

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Zi-Hua Lu

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P2860

Staging of brain pathology related to sporadic Parkinson's disease

Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

Molecular cloning and characterization of a plasma membrane-associated sialidase specific for gangliosides.

Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+).

Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder.

Brain gangliosides in axon-myelin stability and axon regeneration.

Ganglioside GM1 binds to the Trk protein and regulates receptor function.

Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.

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1997-2008

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10.1002/JNR.23090

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10

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90

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2012-06-20T00:00:00Z

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22714832

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Parkinson's disease